|
KMID : 0359920070260050541
|
|
Korean Journal of Nephrology
2007 Volume.26 No. 5 p.541 ~ p.547
|
|
|
Effects of Spironolactone on the Urinary Excretion of TGF-β1 in IgA Nephropathy
|
|
Chung Kyung-Hwan
Park Mi-Na
Moon Ju-Young
Lee Sang-Ho
Lee Tae-Won
Ihm Chun-Gyoo
|
|
|
Abstract
|
|
|
Purpose : Transforming growth factor-β1 (TGF-β1) has an important role in the pathogenesis of renal damage; it enhances extracellular matrix production. Urinary TGF-β1 excretion has been shown to be significantly increased in patients with IgA nephropathy. The aim of the present study was to evaluate the effect of spironolactone on urinary TGF-β1 levels in patients with IgA nephropathy.
Methods : TGF-β1 was measured by enzyme-linked immunosorbent assay in random urine specimens from 35 patients with IgA nephropathy. The patients were assigned to a spironolactone group, prednisolone group or losartan group. They were treated over an 8-week period. Urine samples were tested at the beginning and the end of the treatment period.
Results : The patients with IgA nephropathy (n=35) had a higher urinary excretion of TGF-β1 than normal controls (n=13). Urinary TGF-β1 excretion was positively correlated with proteinuria and pathological grading but not with serum creatinine. After 8 weeks of treatment, losartan (n=13) and prednisolone (n=11) therapy induced a significant reduction in both urinary protein and TGF-β1 excretion. After treatment with spironolactone (n=11), urinary protein and TGF-β1 excretion were decreased. However, the decrease was not statistically significant. There was a significant correlation between the urinary TGF-β1 excretion and the serum aldosterone (r=0.84; p<0.01); however, treatment with spironolactone abolished this correlation.
Conclusion : This study provides evidence that endogenous aldosterone influences urinary TGF-β1
excretion in patients with IgA nephropathy.
|
|
|
KEYWORD
|
|
|
Glomerulonephritis, IgA, Transforming growth factor beta 1, Spironolactone
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|